Is Ibuprofen As Deadly As Vioxx?
An alarming study of the painkillers we often use without question!
How Coxibs Killed Tens of Thousands
Non-steroidal anti-inflammatory drugs (NSAIDs),
which include over-the-counter pharmaceuticals such as ibuprofen,
naproxen, and aspirin, rank among the most widely used pharmaceuticals
worldwide. Their chief mechanism of action is inhibition of two forms of
cyclo-oxygenase (COX), namely COX-1 and COX-2 (1). Also known as
prostaglandin-endoperoxide synthase (PTGS), COX is responsible for the
production of downstream mediators of pain and inflammation, such as
thromboxane and prostaglandins. Due to their suppression of
prostaglandins, which exert protective roles in the gastrointestinal
tract, one of the most frequent adverse effects of NSAIDs is irritation
of the gastric mucosa.
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