Turmeric Extract May Prevent, Even Reverse Diabetes (Type 1 and 2)

Turmeric

 Turmeric is an age-old remedy with so many benefits, not just for Diabetes but for general health!

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Friday, September 6th 2019 at 6:15 am

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Sayer Ji, Founder

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What if the long sought after "cure" for diabetes was as safe, affordable, and accessible as a spice sitting in your kitchen cupboard?

"Leave your drugs in the chemist's pot if you can cure the patient with food." -Hippocrates, 420 BC

Slowly but surely the world is waking up to the reality that diabetes is not only a preventable but a reversible condition, and that the drug-based model of symptom suppression and disease management has fatal flaws. For instance, some of the drugs used to treat type 2 diabetes actually increase the risk of death, with a recent study showing GMO insulin given to type 2 diabetics may lead to the development of so-called "double diabetes": type 2 and type 1 diabetes, together. Clearly, if medicine can't at least abide by its founding principle to "do no harm," it must seek the answer somewhere other than from the "chemist's pot."

As the pharmaceutically-driven medical paradigm continues to lose adherents by the droves, and the public seeks a system that identifies and resolves the root causes of disease, interest is growing in the use of natural substances and lifestyle modifications to prevent and treat blood sugar disorders. And unlike a few decades ago, where most of the evidence for "natural healing" was anecdotal, there are now thousands of studies on hundreds of natural substances and therapeutic activities that may ameliorate blood sugar disorders and their complications. You can check out a good portion of the relevant research on the topic on GreenMedInfo.com's blood sugar disorder database.

While plants like cinnamon and gymnema sylvestre have received plenty of attention for diabetes over the years, one special plant extract that is beginning to stand out from the crowd as being exceptionally valuable as an anti-diabetic agent is turmeric. There are, in fact, 21 articles on turmeric's value in type 2 diabetes on our database alone.

Turmeric's primary polyphenol curcumin is the main compound in the plant that has been researched for it's blood sugar regulating properties. One particularly striking study, published in the American Diabetic Association's own journal, Diabetes Care, found turmeric extract to be 100% effective in preventing pre-diabetics from developing type 2 diabetes -- a feat of prevention that no FDA approved drug for type 2 diabetes has yet come even close to accomplishing.

Turmeric Extract May Reverse Pancreatic Damage In Type 1 Diabetes

It turns out that this spice may be a powerful therapeutic intervention for more than just type 2 diabetics. Pre-clinical research now reveals it may have a role in reversing pancreatic damage in insulin-dependent, type 1 diabetics, who are routinely told that their condition can not be cured. Type 1 diabetics are rarely educated to the fact that the root cause of their disorder can be addressed: namely, that the deficiency and/or dysfunction of the beta cells in the pancreas responsible for producing insulin can be repaired, as well as the autoimmune issues at the heart of the problem.  

Back in 2013, an exciting study published in the journal Diabetology & Metabolic Syndrome titled, "The effect of a novel curcumin derivative on pancreatic islet regeneration in experimental type-1 diabetes in rats (long term study)," found that diabetic rats who received a novel water-soluble, high concentrate (53.21%) curcumin derivative orally for 40 days showed an improvement of their plasma glucose, insulin and C-peptide (a marker for the health and insulin producing capability of the beta cells) levels, that began after about 4 months, and continued to improve until the 10 month mark, when their values were almost completely normalized and evidence of significant pancreatic regeneration could be observed. The researchers concluded the novel curcumin derivative (NCD): "...possesses antidiabetic actions and enhanced pancreatic islets regeneration."

The daily dose used in this rodent study (80 mg/kg) was the body weight equivalent of 6,400 mg or 6.4 grams of curcumin for an average North American male adult (80 kilograms/176 lbs). Rodent and human physiology is, of course, radically different, but significant crossovers nonetheless do exist. In another article, titled "Why Turmeric May Be the Diseased Liver's Best Friend," we reviewed research indicating that turmeric may help to reverse damage in and even regenerate the diabetic liver, as well as safety literature on what is a safe human dose: 

"A 2001 study in cancer patients reported that quantities of curcumin up to 8 g, administered per day for three months, were not toxic and resulted in significant anti-cancer properties in a number of those treated.[5] Considering that turmeric is only 3-4% curcumin by weight, this implies that a larger quantity of turmeric can be consumed safely, as well."

Given that organ transplantation (pancreatic islet transplants) is exceedingly expensive and prohibitive due to a lack of donor material and the potential for rejection by the host, the notion that a safe, affordable, and non-prescription spice extract like curcumin may have significant therapeutic value and may even regenerate damaged pancreatic tissue, is truly exciting. That said, it should be noted that since curcumin is not patentable, it is unlikely the 800 million dollars or more needed to fund the requisite clinical trials needed to obtain FDA drug approval will materialize. Because the so-called "evidence" needed to justify the use of a new treatment is locked behind an insurmountably high paywall, don't count on randomized, controlled, trials being performed on this "natural cure" in the near or distant future. 

In this study, the authors surmised that the ameliorative effects curcumin treatment on type 1 diabetic rodents observed were the result of beta cell regeneration and they explained the theory behind how this works:

"Each tissue or organ is believed to contain a small sub-population of cells that is capable of self-renewal and has the ability to give rise to each mature cell type [47]. Thus, one of the most promising sources of beta cells might be pancreatic stem cells."

The researchers theorized that curcumin likely produces,

"...a favorable systemic and pancreatic environment to foster bone marrow transplantation and islet neogenesis. Accordingly, administration of curcumin; as an established anti-inflammatory and immune modulatory drug; would likely boost and preserve the process of islet regeneration; which was evidently proven true in this study."

Curcumin's "immunomodulatory" benefit in type 1 diabetes, also known as autoimmune diabetes, appears to be based on it reducing the activity of the host immune system in attacking self-structures. In fact, another recent study, published in 2014 in the journal Clinical and Experimental Immunology titled, "Curcumin ameliorates autoimmune diabetes. Evidence in accelerated murine models of type 1 diabetes," found that curcumin down-regulates the T cell response that destroys pancreatic beta cells, resulting in an improvement in autoimmune or type 1 diabetes.

It is important for the reader to know that curcumin is not a magic bullet; nor is it the only natural substance studied to have potential beta cell regenerative properties. Indeed, pancreatic regeneration has been induced experimentally for at least 23 different natural substances. We have a keyword dedicated to indexing relevant research on the topic here: beta cell regeneration. We've highlighted 10 of the most compelling ones in our article, "10 Natuaral Substances That Could Help Cure Type 1 Diabetes."

As the research continues to accumulate on the value of natural substances for disease prevention and treatment, it is clear the future of medicine will rely on returning to the wisdom of the ancients, where Hippocrates' fundamental principle that one can "cure the patient with food" is once again passionately embraced.
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Originally published: 2015-08-30 
Article updated: 2019-09-06

Sayer Ji is founder of Greenmedinfo.com, a reviewer at the International Journal of Human Nutrition and Functional Medicine, Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of the National Health Federation, Steering Committee Member of the Global Non-GMO Foundation.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

Why All Diabetics Should Know About Turmeric

Important Informaton about Diabetes

The healing powers of Turmeric cannot be ignored.

Posted on:

Sunday, November 11th 2018 at 5:00 am

Written By:

Sayer Ji, Founder

This article is copyrighted by GreenMedInfo LLC, 2018
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Many diabetics already know about the benefits of a low-glycemic diet and the need for regular exercise, but why haven't they heard about turmeric, one of the world's most extensively researched anti-diabetic plants?
A recent literature review published in the International Journal of Endocrinology and Metabolism titled, "Anti-Hyperglycemic Effect and Insulin Sensitizing Effects of Turmeric and Its Principle Constituent Curcumin," adds promising new support to the notion that the ancient Indian spice turmeric may provide an ideal drug alternative to treating and perhaps even preventing type 2 diabetes, which has become of the world's most prevalent diagnoses.

The study reviewed research published between 1998 to 2013 that indicates the active polyphenol in turmeric known as curcumin may provide an ideal intervention for type 2 diabetes, capable of mitigating characteristic pathophysiological hallmarks of the disease such as elevated blood sugar (hyperglycemia) and insulin resistance.

Nineteen of the studies reviewed were cell (in vitro) and animal (in vivo), all which showed beneficial effects.  Five of the studies were human clinical trials using turmeric or curcumin, three of which were performed in those with either diabetes or prediabetes.

Amazingly, the animal and cell research literature review concluded that curcumin could improve the type 2 diabetic state through 10 distinctly different mechanisms, such as:

• Reduction in liver glucose production
• Reduction in liver glycogen production
• Stimulation of increased glucose uptake (by increasing GLUT4, GLUT2 and GLUT3 gene expressions)
• Increasing the activation of AMP kinase
• Promoting PPAR γ ligand- binding activity
• Suppressing hyperglycemia-induced inflammatory state
• Stimulating insulin secretion from pancreatic tissues
• Improvement in pancreatic cell function,
• Increasing phosphorylation of AKT
• Increasing insulin receptor β and reduction of insulin resistance

The human clinical research conducted on diabetic and pre-diabetic patients revealed that curcumin had the following beneficial effects:

• Glucose lowering effect
• Improved beta cell function
• Improved fatty acid oxidation and utilization

One of these studies is especially worth highlighting, as it found a turmeric extract was highly effective in preventing the development of diabetes within pre-diabetic subjects. The study published in 2012, in the American Diabetic Association's own journal, Diabetes Care, and titled, "Curcumin extract for the prevention of type 2 diabetes," found that the administration of six capsules containing 250 mg of curcumin daily for 9 months was 100% effective at preventing the development of type 2 diabetes in prediabetics; more specifically: "16.4% of the subjects in the placebo group were diagnosed with T2DM, whereas none were diagnosed with T2DM."

Observed effects like these are extremely promising when viewed within the context of the highly dismal pharmaceutically-based standard of care. For instance, oral anti-diabetic drugs like metformin are notorious for their serious side effects. They often lower blood sugar, generating the surface appearance of physiological normality, e.g. blood sugar within range, but actually increase morbidity and mortality. With the possibility of deadly side effects, we need natural, safe, affordable and easily accessible alternatives like turmeric now more than ever.

Moreover, despite the well known problem of insulin resistance in type 2 diabetes, recombinant or genetically modified insulin is often used in these patients – a highly illogical and irresponsible approach, and which is endemic to a medical paradigm that does not seek to identity for resolve root causes of disease. A small, but highly concerning recent clinical study found that insulin accelerated the progression of type 2 diabetes, as well as caused type 1 diabetes, or "double diabetes."
Diabetes is, of course, driven by a dietary pattern that reflects evolutionary mismatch, i.e. the Western diet is a lethal disease vector that has no resemblance to the traditional diet humans consumed for thousands of years, and upon which it still depends for good health. Turmeric, therefore, while an amazing alternative to diabetic drugs, should not be considered a "natural cure"; rather, it is something of a palliative counter-balance to a biologically inappropriate diet, which while far better than pharmaceuticals (learn more by reading: Science Confirms Turmeric As Effective As 14 Drugs), still needs to be part of a broader, more holistic plan that takes into account diet, exercise, toxicant exposure, and mind-body/emotional factors that underpin well-being and contribute significantly to most dis-eases.

For more information on the therapeutic value of turmeric/curcumin diabetes, read our previous articles on the topic: