Autoimmune Disease
- Date:
- April 19, 2019
- Source:
- Michigan Medicine - University of Michigan
- Summary:
- New evidence points to a key role for a molecular
switch called VGLL3 in autoimmune diseases, and the major gap in
incidence between women and men. Building on past research showing that
women have more VGLL3 in their skin cells than men, a team studied it
further in mice. They show that having too much VGLL3 in skin cells
pushes the immune system into overdrive, leading to an autoimmune
response and symptoms similar to lupus.
It's one of the great mysteries of medicine, and one that affects the lives of millions of people: Why do women's immune systems gang up on them far more than men's do, causing nine times more women to develop autoimmune diseases such as lupus?
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